Recherche

RESEARCH LABORATORY

in Biotechnology & Bioinformatics

LABORATORY ACTIVITIES:

The laboratory activities are mainly focused on the study of antibiotic resistance mechanisms and virulence in Gram negative and positive bacteria

All research projects conducted aim to characte- rize the emergence and diffusion of multiresis- tant clones at the hospital and community level

RESEARCH TOPICS
  • Evolution of antibiotic resistance
  • Characterization of resistance genes: ESBL, CPE, PMQR, VanR and mec A genes

Therapeutic alternatives

  • Identification of natural or synthetic molecules having a bactericidal or antibiofilm effects
  • Biofilm formation ability and quantification
  • Effect of disinfectants on the adhesion and biofilms formation
BIOINFORMATICS ANALYSIS AND COMPUTER-AIDED DRUG DISCOVERY

Understanding resistance mechanisms through molecular modeling and structural analysis

Active site prediction.

Virtual screening based on structure to discover new highly potent antibacterial agents.

Molecular dynamics simulation and calculation of free binding energy.